PLoS One. 2014 Nov 12;9(11):e112676
发布时间:2015-09-26 浏览次数:
 2014 Nov 12;9(11):e112676. doi: 10.1371/journal.pone.0112676. eCollection 2014.

Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study.

Duan G1, Yang H2, Shi L3, Sun W2, Sui M2, Zhang R2, Wang X4, Wang F4, Zhang W2, Xi Y2, Fan Q2.

Author information

  • 1Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China; Henan Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China.
  • 2Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
  • 3Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China; Henan Center for Disease Control and Prevention, Zhengzhou, Henan, China.
  • 4Children's Hospital of Zhengzhou City, Zhengzhou, Henan, China.

Abstract

BACKGROUND:

Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity.

METHODS:

This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels.

RESULTS:

The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD.

CONCLUSIONS:

Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity.